The ability to salvage late-stage germ cells and use adult chimeric hosts opens up a wider array of opportunities to apply genetic rescue to rare birds.Ģ016 – 2017: Phase Two Research with Crystal Bioscienceįor the revival of the Heath Hen, gene-edited cells that can develop into live chicks are needed. If successful, Crystal Biosciences’ cell cultures may yet produce the world’s first greater prairie chickens hatched using biotechnology. Schusser’s lab is currently running control experiments with domestic chickens, and experiments using greater prairie chicken germ-cells will follow. Schusser’s lab will conduct germ-line transfer experiments in adult male domestic chickens, as opposed to the standard embryonic implantation method using primordial-stage germ cells. Benjamin Schusser ’s lab at the Technische Universität München, in Munich Germany. In 2018, in order to capitalize upon the partial success of Crystal Bioscience, Revive & Restore shipped the late-stage germ-cell cultures established in 2016 to Dr. 2018: An Alternative Pathway for Obtaining Primordial Germ Cells The goal is to jump start additional avian genetic projects around the world that will advance biotechnologies for a wide range of endangered and extinct birds. This avian genetic rescue program will not only build upon the work of Crystal Bioscience, but also serve as a model for other avian species. Rosemary Walzem of Texas A&M University to develop and optimize techniques to enable germline transmission of primordial germ cells for avian genetic rescue applications, using the greater prairie chicken as the model species. Revive & Restore’s recently established Catalyst Fund Program awarded a two-year grant to Dr. Meanwhile alternative protocols for germ-line transmission were explored with international partners (see 2018 below). With bench-work paused, Revive & Restore leveraged the initial Heath Hen de-extinction work into an avian genetic rescue program, secured a new academic partner, and raised the necessary funding to proceed with the first key milestone. Initial phase two lab work was paused in early 2017 after our avian genetics partner Crystal Bioscience was acquired and could no longer work on our project. The key milestone of Phase Two is successfully culturing the primordial germ cells (PGCs) of the greater prairie chicken, the proximate species to the Heath Hen.
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